Biomedical and Translational Sciences Division

Dean: William Mayhan, Ph.D.
Associate Dean: Daniel Bird, Ph.D.

Sanford School of Medicine of the University of South Dakota
Division of Biomedical and Translational Sciences
414 East Clark Street
Vermillion, SD 57069
Phone: 605-658-6400
Fax: 605-677-6381
Email: biomed@usd.edu (M.S. or Ph.D. inquiries) or MDPhD@usd.edu (M.D./Ph.D. inquiries)
https://usd.edu/biomed

FACULTY

For a current listing of faculty members, please see www.usd.edu/medicine/basic-biomedical-sciences.

DEGREE

Master of Science
Doctor of Philosophy
M.D./Ph.D. (Physician Scientist Program)

SPECIALIZATION

Cancer Biology
Cardiovascular Biology
Infectious Diseases (formerly Microbiology and Immunology)
Molecular Biology & Genetics
Neuroscience
Physiology and Pharmacology

Additional Areas of Study

Cellular Biology
Systems Physiology and Structural Biology
Synthetic, Systems, and Computational Biology

Program Description

The Biomedical and Transational Sciences program provides interdisciplinary graduate education in a variety of biomedical science areas. The program stresses laboratory investigation and original research under the direction of a faculty member. The Division of Biomedical and Translational Sciences also emphasizes flexibility and individual choice in the development of the student’s overall program of study. At the present time, Division faculty are conducting research in the broad areas of Cancer Biology, Cellular Biology, Molecular Biology & Genetics, Infectious Diseases (formerly Microbiology/Immunology), Neuroscience, Physiology and Pharmacology, and Systems Physiology and Structural Biology. More specific information on faculty and student research interests can be found at www.usd.edu/medical-school/biomedical-sciences/.

The program offers the Ph.D. and M.S. degrees, although emphasis is placed on the Ph.D. program of study. In the first year of the Ph.D. program, students take a set of core courses directed at providing information and skills necessary for success in the biomedical sciences. This is supplemented with introductory graduate courses in the student’s area of research interest.

In the second year, students typically complete the majority of courses specific to their area of interest and finalize the selection of a faculty mentor to oversee their laboratory research. Courses are available in the areas of anatomy and structural biology (ANAT), biochemistry and molecular biology (BIOC), microbiology and immunology (MICR), neurosciences (NSCI), physiology and pharmacology (PHGY, PHAR, PHPH) and the combined program (CPHD). Students in the Ph.D. program also take a qualifying examination, prepare a written research proposal and participate in seminars and journal clubs offered by the Division.

The Sanford School of Medicine received approval to offer an M.D./Ph.D. to prepare students for careers as Physician Scientists. Physician Scientists play a unique role in contemporary medical research, having received extensive training in both medicine and fundamental research. Students admitted to the program will perform original research in one of the laboratories of Sanford School of Medicine and participate in the academic programs required for the M.D. and Ph.D. programs, including several courses specific for students in this program.

WICHE Western Regional Graduate Program (WRGP) eligible program.

ADMISSION REQUIREMENTS

Completed Graduate Application form found at: https://www.usd.edu/grad/how-to-apply and a non-refundable application fee of $35.
Official transcript(s) verifying receipt of an undergraduate degree and previous graduate credit (in English or with translation). Transcripts must be complete (e.g., if currently enrolled, work-in-progress coursework must be included, foreign transcripts must include a grading scale, and for countries that issue, copy of degree certificate/diploma i.e., India, Nepal, etc.). The USD Graduate School and/or academic units retain the right to require credential evaluations from organizations, such as Educational Credential Evaluators/World Education Services (ECE/WES), for a student if such an evaluation is deemed necessary.
Applicants must have a baccalaureate degree from an institution with institutional accreditation for that degree. A minimum undergraduate cumulative GPA of 2.7 on conferred degree and/or graduate cumulative GPA of 3.0 or better, based on a 4.0 scale, on all graduate coursework is required for full admission. Each graduate program may admit students on provisional status per university policy.
Applicants with degrees from countries other than the United States who have obtained a high school diploma, undergraduate, or graduate degree from an institutionally accredited American college or university or from an accredited institution in the approved list of English-speaking countries are not required to submit an approved English proficiency exam score. For all other applicants with degrees from other countries, a minimum score of 79 on the Internet-Based TOEFL (iBT), 550 on the Paper-Based TOEFL (PBT), 8.5 on the TOEFL Essentials, 6.0 on the IELTS Academic, 53 on the PTE, or 110 on Duolingo is required for graduate admission.

Additional Program Admission Requirements:

Applicants are required to submit a statement of purpose.  A statement of purpose should articulate how your background, expertise, and aspirations align with your decision to pursue graduate studies at USD’s Biomedical and Translational Sciences Graduate Program. For the PhD and MSc-with thesis, you should highlight how your past research experience has equipped you with the necessary skills and knowledge to succeed in the program. Provide details on how your research area, methodologies, and outcomes have informed your academic and career goals, and how these relate to the research and educational opportunities available at USD. This should be a 1-2 page single spaced document.
Resume.
Three (3) professional letters of recommendation are required.

Subject to faculty approval, those who do not meet all of the criteria above may be admitted on a provisional basis.

Application Deadline for M.S. and Ph.D. Programs

Fall Only:

April 1st (Ph.D.) decisions are made by May 15th 
June 1st (M.S.) (international students must follow stated international admission deadlines which may vary from program admission deadlines)

ADMISSION REQUIREMENTS FOR THE PHYSICIAN-SCIENTIST (M.D./Ph.D.) PROGRAM

Applicants interested in the Physician Scientist (M.D./Ph.D.) program apply to the Sanford School of Medicine through the American Medical College Application Service (AMCAS). All application materials must be submitted to AMCAS by the deadline posted at: https://www.usd.edu/Academics/Graduate-Programs/Physician-Scientist . The course prerequisites, technical standards and MCAT requirement of the M.D. program are minimal prerequisites and requirements of the Physician Scientist program. Although no minimal grade point average or MCAT score is required, it is expected that competitive applicants will have a strong academic record. Beyond the core academic requirements, the most important factor for admission will be the potential of the applicant to become an independent researcher, as demonstrated by excellence in research experience prior to the application process. The secondary application includes special instructions for applying to the Physician Scientist program. The secondary application will be sent to the applicant electronically upon receipt at Sanford School of Medicine of an AMCAS-verified application to the Physician Scientist program. The deadline for receipt of the completed secondary application is November 15. The supplemental application must include additional information required for admission to the M.D. and M.D./Ph.D. training programs, two letters of reference by individuals qualified to evaluate the applicant’s research potential, a statement of research interest, career goals and special qualifications for the program written by the student, and a detailed report of the student’s previous research experience. Consideration to the Physician Scientist program is independent of admission to the M.D. program or the Ph.D. program offered at the University of South Dakota. Students interested in being considered for admission to either or both of the separate degree programs must clearly indicate this on their applications and supplemental materials. Acceptance to the Physician Scientist program confers acceptance only for the student positions assigned to the Physician Scientist program. For more information, contact MDPhD@usd.edu.

Subject to faculty approval, those who do not meet all of the criteria above may be admitted on a provisional basis.

Application Deadline for Physician Scientist Program (M.D./Ph.D.)

See deadlines at https://www.usd.edu/Academics/Graduate-Programs/Physician-Scientist

Physician Scientist (M.D./Ph.D.)

The Sanford School of Medicine Physician Scientist program is a modified 2-3-2 program of study that combines course work and research activities over seven years. The program consists of two years of preclinical coursework followed by three years of Ph.D. research, followed by two years of clinical coursework. The M.D. degree is graded pass/fail for Pillar 1 and the first semester of Pillar 2. The entire Ph.D. degree and M.D. second semester Pillar 2, and all of Pillar 3 are graded based on a 4.0 grade point scales. For more information about the Physician Scientist degree requirements, contact MDPhD@usd.edu.

Research Expertise Available

Expertise for research and training are found within the Division for the following areas: bacterial host-parasite interactions, cardiovascular development, cardiovascular disease, central control of blood pressure, control of respiration, endocrinology mechanisms of DNA repair, gastrointestinal physiology and pharmacology, gene expression, genetic control of myelin development, microbial genetics, microbial physiology, mitochondrial function, neural mechanism of motor control, neural mechanisms of learning and memory, prostate growth and development, protein folding and processing, regulation of cellular growth, regulation of higher order behaviors, signal transduction, viral immunology, and wound healing and tissue regeneration.

Research Facilities Available

Facilities are available to support ongoing research in each of the areas listed above. Division imaging resources include confocal and epifluorescence microscopes, multiple Bio-Rad and LiCOR imagers for chemiluminescence, fluorescence, bioluminescence, and infrared imaging with computer-based densitometry analysis, and a Bio Tek Cytation-1 multimode reader for advanced cellular analysis with computer-based 3-D reconstructions. Molecular biology research is supported with equipment for nucleic acid quality assessment, Alligent real-time PCR instruments, Illumina next-generation sequencing, gel electrophoresis, dedicated Laminar Flow cell culture hoods, BD Biosciences fluorescence-activated cell sorters, and Agilent Seahorse and Xcelligence instruments for cellular metabolism and function studies. Physiology and animal research facilities include electrophysiological and physiological recording systems, dedicated animal surgery suites with anesthesia capabilities, in vivo fluorescence, micro-ultrasound, and laser Doppler imaging systems. Behavioral testing facility supports neuroscience and animal behavioral assessments. Proteomic and mass spectrometry resources include Thermo Scientific UHPLC coupled to two Orbitrap HR/MA mass spectrometers, a ProteomeWorks spot cutter, a GE Healthcare Typhoon 9410 Imager, an Agilent GelFree 8100 fractionation system, and bioinformatics tools for diverse proteomics approaches, including labeled and label-free studies, interactomics, and gene ontology/pathway analysis. Supporting resources also include high-speed/ultracentrifuges and various spectrophotometers (UV, visible, infrared).

Student Learning Outcomes for Biomedical and Tranlational Sciences (M.S.)

Critically apply knowledge to address fundamental questions in their primary area of study. 
Pursue research of significance in their discipline of interest. Students plan and conduct this research or implement this project under the guidance of an advisor while developing the intellectual independence that typifies true scholarship. 
Demonstrate skills in oral and written communication sufficient to publish and present original work in their field. 
Follow the principles of responsible conduct of biomedical research.

Student Learning Outcomes for Biomedical and Translational Sciences (Ph.D.)

Critically apply knowledge to address fundamental questions in their primary area of study. 
Pursue research of significance in their discipline of interest. Students plan and conduct this research or implement this project under the guidance of an advisor while developing the intellectual independence that typifies true scholarship.   
Demonstrate skills in oral and written communication sufficient to publish and present original work in their field and to prepare grant proposals. 
Follow the principles of responsible conduct of biomedical research.